Cyproterone acetate是一种合成类固醇化合物，兼具强效抗雄激素活性（对雄激素受体的半数抑制浓度IC50为7.1 nM）与孕激素样作用。该化合物还能与孕酮受体及糖皮质激素受体发生交叉结合，表现出多重的激素调节特性。
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英文别名 (English Synonym) |
Cyproterone Acetate |
|
中文名称 (Chinese Name) |
醋酸环丙氯地孕酮, 醋酸环丙孕酮 |
|
靶点 (Target) |
Androgen Receptor |
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通路 (Pathway) |
Endocrinology and Hormones |
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CAS号 (CAS NO.) |
427-51-0 |
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分子式 (Formula) |
C24H29ClO4 |
|
分子量 (Molecular Weight) |
416.94 |
|
纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Takiguchi M, Cherrington NJ, Hartley DP, Klaassen CD, Waalkes MP. Cyproterone acetate induces a cellular tolerance to cadmium in rat liver epithelial cells involving reduced cadmium accumulation. Toxicology. 2001 Aug 13;165(1):13-25. doi: 10.1016/s0300-483x(01)00402-4. PMID: 11551428. [2] Migally N. Effect of cyproterone acetate on the structure of the adrenal cortex. Arch Androl. 1979 Mar;2(2):109-15. doi: 10.3109/01485017908987301. PMID: 485632.
