Finasteride（MK-906）是一种口服有效的竞争性5α-还原酶抑制剂，其对II型5α-还原酶的半数抑制浓度（IC50）为4.2 nM，且对该亚型的抑制活性约为I型酶的100倍。该药物临床主要用于良性前列腺增生及雄激素性脱发的相关研究。
|
英文别名 (English Synonym) |
Finasteride |
|
中文名称 (Chinese Name) |
非那雄胺 |
|
靶点 (Target) |
5-alpha Reductase |
|
通路 (Pathway) |
Endocrinology and Hormones |
|
CAS号 (CAS NO.) |
98319-26-7 |
|
分子式 (Formula) |
C23H36N2O2 |
|
分子量 (Molecular Weight) |
372.54 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Yun DK, Lee J, Keum YS. Finasteride Increases the Expression of Hemoxygenase-1 (HO-1) and NF-E2-Related Factor-2 (Nrf2) Proteins in PC-3 Cells: Implication of Finasteride-Mediated High-Grade Prostate Tumor Occurrence. Biomol Ther (Seoul). 2013 Jan;21(1):49-53. doi: 10.4062/biomolther.2012.080. PMID: 24009858; PMCID: PMC3762299. [2] Sirinarumitr K, Johnston SD, Kustritz MV, Johnston GR, Sarkar DK, Memon MA. Effects of finasteride on size of the prostate gland and semen quality in dogs with benign prostatic hypertrophy. J Am Vet Med Assoc. 2001 Apr 15;218(8):1275-80. doi: 10.2460/javma.2001.218.1275. PMID: 11330612.
