Megestrol acetate 是一种口服有效的合成孕激素类药物，具有刺激食欲的作用，常用于恶病质等消耗综合征的临床研究。该化合物能够下调雄激素受体在细胞核与胞质中的活性，在艾滋病相关消耗症的治疗中显示应用潜力，并通过抑制自噬分解代谢途径发挥作用。
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英文别名 (English Synonym) |
Megestrol Acetate |
|
中文名称 (Chinese Name) |
醋酸甲地孕酮 |
|
靶点 (Target) |
Estrogen/progestogen Receptor |
|
通路 (Pathway) |
Endocrinology and Hormones |
|
CAS号 (CAS NO.) |
595-33-5 |
|
分子式 (Formula) |
C24H32O4 |
|
分子量 (Molecular Weight) |
384.51 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Panasci L, Jean-Claude BJ, Vasilescu D, Mustafa A, Damian S, Damian Z, Georges E, Liu Z, Batist G, Leyland-Jones B. Sensitization to doxorubicin resistance in breast cancer cell lines by tamoxifen and megestrol acetate. Biochem Pharmacol. 1996 Oct 11;52(7):1097-102. doi: 10.1016/0006-2952(96)00456-x. PMID: 8831729. [2] Beck SA, Tisdale MJ. Effect of megestrol acetate on weight loss induced by tumour necrosis factor alpha and a cachexia-inducing tumour (MAC16) in NMRI mice. Br J Cancer. 1990 Sep;62(3):420-4. doi: 10.1038/bjc.1990.310. PMID: 2206950; PMCID: PMC1971439.
