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IC-87114 (IC87114)是细胞渗透性PI3Kδ选择性抑制剂，IC₅₀为0.5 μM，比作用于其他PI3K亚型选择性高50倍。在中性粒细胞中，IC87114能够减少FMLP诱导的PIP3的合成和趋化作用。

参考文献

[1] Sadhu C, et al. Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J Immunol. 2003 Mar 1;170(5):2647-54.

[2] Sujobert P, et al. Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. Blood. 2005 Aug 1;106(3):1063-6.

[3] El-Hashim AZ, et al. Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1/2, PI3Kδ/Akt and NFκB induction in a murine asthma model. Sci Rep. 2017 Aug 30;7(1):9919.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。