OSI-420 (Desmethyl Erlotinib hydrochloride; CP-373420 hydrochloride)是Erlotinib的活性代谢产物。Erlotinib是EGFR抑制剂（酪氨酸激酶抑制剂），其IC₅₀值为2 nM。

参考文献

[1] Ali S, et al. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Mol Cancer Ther. 2008 Jun;7(6):1708-19.

[2] Buck E, et al. Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors. Mol Cancer Ther. 2006 Nov;5(11):2676-84.

[3] Meany HJ, et al. The plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite (OSI-420) after intravenous administration of erlotinib in non-human primates. Cancer Chemother Pharmacol. 2008 Aug;62(3):387-92.

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