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Mitochonic acid 5 (MA-5, MA5)线粒体ATP生成增强剂，通过靶向线粒体蛋白mitofilin促进ATP的产生，并降低了ROS水平，挽救心脏和肾脏线粒体呼吸；Mitochonic acid 5还可上调线粒体自噬，促进细胞存活。Mitochonic acid 5促进ATP合酶寡聚和与线粒体蛋白/Mic60形成超复合体。

参考文献

1.Suzuki T, et al. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage. J Am Soc Nephrol. 2016 Jul;27(7):1925-32.

2.Lei Q, et al. Mitochonic acid 5 activates the MAPK-ERK-yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy. Cell Mol Biol Lett. 2018 Apr 5;23:14.

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