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Obeticholic Acid (INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid)，又称奥贝胆酸或6-乙基鹅去氧胆酸，人初级胆汁酸中鹅脱氧胆酸(CDCA)的新型衍生物，是farnesoid X receptor (FXR)选择性激动剂，EC₅₀值为99 nM，通过活化FXR，间接抑制CYP7A1表达，进而抑制胆酸合成，临床上常用来治疗胆汁淤积性肝病。

参考文献

1. Pellicciari R, et al. 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. J Med Chem. 2002 Aug 15;45(17):3569-72.
2. Fiorucci S, et al. Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis. J Pharmacol Exp Ther. 2005 May;313(2):604-12.
3. Ghebremariam YT, et al. FXR agonist INT-747 upregulates DDAH expression and enhances sensitivity in high-salt fed Dahl rats. PLoS One. 2013 Apr 4;8(4):e60653.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。