Natural pollen extract for photothermal therapy
Yao Yang, Qianwen Zhang, Junwen Zhang, Anqi Chen, Yanxin Chen, Shengyu Li, Mingde Ye, Xuan Xuan, Xiaokun Li, Huacheng He, Jiang Wu
Journal：MATERIALS & DESIGN
IF：7.99
DOI：10.1016/j.matdes.2021.109573
PMID：
Published：2021-02-10
research field：肿瘤学癌症代谢分子生物学转录调控泛素-SUMO信号通路
Abstract
Herein, we discovered that the sunflower sporopollenin exine capsule (SEC) is an effective photothermal agent. In vitro study finds that the spikes on the surface of the sunflower SEC and its structural integrity are the two key factors to determine the photothermal effect. In vivo melanoma mouse model proves that the sunflower SEC can effectively inhibit tumor growth by inducing cell apoptosis and reducing cell proliferation through the near-infra red light triggered photothermal therapy. The in vivo biosafety of the SEC is also validated. In consideration of its safety, uniform size distribution and abundant availability, the sunflower SEC will be a promising photothermal agent candidate for clinical translational application.
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