Torcetrapib (CP-529414)是一种有效且选择性的胆固醇酯转移蛋白 (CETP) 抑制剂,在人血浆中对CETP的最有效抑制浓度为37 nM。
|
英文别名 (English Synonym) |
Torcetrapib |
|
中文名称 (Chinese Name) |
托彻普 |
|
靶点 (Target) |
CETP |
|
通路 (Pathway) |
Protease/Metabolic Enzyme |
|
CAS号 (CAS NO.) |
262352-17-0 |
|
分子式 (Formula) |
C26H25F9N2O4 |
|
分子量 (Molecular Weight) |
600.47 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Esau L, Sagar S, Bangarusamy D, Kaur M. Identification of CETP as a molecular target for estrogen positive breast cancer cell death by cholesterol depleting agents. Genes Cancer. 2016 Sep,7(9-10):309-322. doi: 10.18632/genesandcancer.122. PMID: 28050232, PMCID: PMC5115172.[2]Clark RW, Sutfin TA, Ruggeri RB, Willauer AT, Sugarman ED, Magnus-Aryitey G, Cosgrove PG, Sand TM, Wester RT, Williams JA, Perlman ME, Bamberger MJ. Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapib. Arterioscler Thromb Vasc Biol. 2004 Mar,24(3):490-7. doi: 10.1161/01.ATV.0000118278.21719.17. Epub 2004 Jan 22. PMID: 14739125.
