马来酸茚达特罗（QAB149）是一种口服有效的超长效β2-肾上腺素受体（ADRB2）激动剂，它通过β-arrestin2依赖的方式抑制NF-κB活性，从而防止肺部损伤并改善慢性阻塞性肺病（COPD）患者的肺功能，同时也可用于心血管疾病的研究。
|
英文别名 (English Synonym) |
Indacaterol Maleate |
|
中文名称 (Chinese Name) |
马来酸茚达特罗 |
|
靶点 (Target) |
Adrenergic Receptor |
|
通路 (Pathway) |
GPCR/G protein |
|
CAS号 (CAS NO.) |
753498-25-8 |
|
分子式 (Formula) |
C24H28N2O3·C4H4O4 |
|
分子量 (Molecular Weight) |
508.56 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Lee SU, Ahn KS, Sung MH, Park JW, Ryu HW, Lee HJ, Hong ST, Oh SR. Indacaterol inhibits tumor cell invasiveness and MMP-9 expression by suppressing IKK/NF-κB activation. Mol Cells. 2014 Aug;37(8):585-91. doi: 10.14348/molcells.2014.0076. Epub 2014 Aug 18. PMID: 25134539; PMCID: PMC4145369.[2]Ye Y, Gong H, Wang X, Wu J, Wang S, Yuan J, Yin P, Jiang G, Li Y, Ding Z, Zhang W, Zhou J, Ge J, Zou Y. Combination Treatment With Antihypertensive Agents Enhances the Effect of Qiliqiangxin on Chronic Pressure Overload-induced Cardiac Hypertrophy and Remodeling in Male Mice. J Cardiovasc Pharmacol. 2015 Jun;65(6):628-39. doi: 10.1097/FJC.0000000000000230. PMID: 25806688; PMCID: PMC4461387.
