Budesonide是一种吸入式且具有口服活性的糖皮质激素受体激动剂。作为哮喘抗炎药,它还能减少肺部肿瘤大小、逆转DNA低甲基化并调节基因mRNA表达。
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英文别名 (English Synonym) |
Budesonide |
|
中文名称 (Chinese Name) |
布地奈德 |
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靶点 (Target) |
Glucocorticoid Receptor |
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通路 (Pathway) |
GPCR/G protein |
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CAS号 (CAS NO.) |
51333-22-3 |
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分子式 (Formula) |
C25H34O6 |
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分子量 (Molecular Weight) |
430.53 |
|
纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Dong L, Zhu YH, Liu DX, Li J, Zhao PC, Zhong YP, Chen YQ, Xu W, Zhu ZQ. Intranasal Application of Budesonide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing Nucleotide-Binding Oligomerization Domain-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation in Mice. J Immunol Res. 2019 Feb 27,2019:7264383. doi: 10.1155/2019/7264383. PMID: 30937316, PMCID: PMC6415278.[2]Pereira MA, Tao L, Liu Y, Li L, Steele VE, Lubet RA. Modulation by budesonide of DNA methylation and mRNA expression in mouse lung tumors. Int J Cancer. 2007 Mar 1,120(5):1150-3. doi: 10.1002/ijc.22468. PMID: 17163412.
