永利3044(中国集团)有限公司官网

IOX2是HIF-1α脯氨酰羟化酶-2 (PHD2)抑制剂，IC₅₀为21 nM。在氧分压正常的条件下，PHD2通过氧依赖性途径促使HIF-1α蛋白酶体降解，而缺氧抑制PHD活性，增加HIF转录复合物的丰度和活性。

参考文献

[1] Murray JK, Balan C, Allgeier AM, et al. Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity. J Comb Chem. 2010 Sep 13;12(5):676-86. doi: 10.1021/cc100073a.

[2] Deppe J, Popp T, Egea V, et al. Impairment of hypoxia-induced HIF-1α signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol. 2016 May;90(5):1141-50. doi: 10.1007/s00204-015-1549-y(IF:5.741).

-25~-15℃保存，有效期3年。