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Bortezomib (PS-341, LDP-341, NSC 681239, PS341, LDP341, NSC681239, Velcade)，又称硼替佐米或保特佐米，一种硼酸二肽，是可逆的26S蛋白酶体选择性抑制剂，通过靶向苏氨酸残基有效抑制20S蛋白酶体，导致蛋白无法降解而累积，进而诱导细胞凋亡，具有抗癌活性，临床上是用于治疗多发性骨髓瘤。

参考文献

1. Adams J, et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999 Jun 1;59(11):2615-22.
2. Pérez-Galán P, et al. The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status. Blood. 2006 Jan 1;107(1):257-64.
3. Yerlikaya A, et al. Combined effects of the proteasome inhibitor bortezomib and Hsp70 inhibitors on the B16F10 melanoma cell line. Mol Med Rep. 2010 Mar-Apr;3(2):333-9.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。