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iCRT14 (iCRT-14)是β-catenin/Tcf的抑制剂，IC₅₀为40.3 nM，属于噻唑烷二酮类小分子化合物，抑制β-catenin应答转录。iCRT14还抑制TCF和DNA的结合。Wnt信号调节大量的基本发育和细胞生物学过程，异常或持续的Wnt信号与多种肿瘤有关。

参考文献

1.Gonsalves FC, et al. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci USA. 2011 Apr 12;108(15):5954-63.

2.Bilir B, et al. Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells. J Transl Med. 2013 Nov 4;11:280.

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