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SANT-1能直接结合到Smoothened (Smo)受体，K_d为1.2 nM，是一种有效Smo拮抗剂，IC₅₀值为20 nM，抑制Hedgehog通路。在Shh-LIGHT2和SmoA1-LIGHT2细胞系中，SANT-1有效抑制SAG诱导的的通路激活。

参考文献

1.James K. Chen, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci USA, 2002;99(22), 14071-14076.

2.Wilson CW, et al. Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS One. 2009;4(4):e5182.

3.Chun SG, et al. Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer. Cancer Biol Ther. 2009;8: 1328-39.

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃避光保存，避免反复冻融。