R-Spondin2 (RSPO2) is a member of the R-Spondin family and is a secreted protein that plays a crucial role in regulating Wnt/β-catenin signaling. In mice, R-Spondin2 is essential for various developmental processes. For example, it is required for the maintenance of the apical ectodermal ridge in the hindlimb, which is critical for proper limb development. Additionally, R-Spondin2 is involved in the development of the larynx, trachea, lung, and other organs. It also plays a role in bone formation and mineralization by enhancing Wnt/β-catenin signaling.R-Spondin2's ability to enhance Wnt signaling makes it a potential candidate for promoting tissue regeneration and repair. It can be used to stimulate osteoblast differentiation and bone formation, which is beneficial for treating bone-related disorders. Also, R-Spondin2 is involved in the regulation of stem cell proliferation and differentiation. Its role in Wnt signaling can be exploited to study cancer stem cells and develop targeted therapies for cancers that involve dysregulated Wnt pathways
高活性、高纯度、低内毒素、高批间一致性
SDS-PAGE
2 μg/lane protein was resolved with SDS-PAGE under non-reducing (NR) and reducing (R) conditions and visualized by Coomassie Blue staining.
SEC-HPLC
The purity of Mouse RSPO2 is greater than 95% as determined by SEC-HPLC.
RP-HPLC
The purity of Mouse RSPO2 is greater than 95% as determined by RP-HPLC.
Bioactivity
Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. The typical EC50 is less than 10ng/ml in the presence of 5ng/ml Recombinant Human Wnt Surrogate.
-25 ~ -15℃保存，收到货之后有效期1年。复溶后， 2 ~ 8 °C保存，7 天有效期。复溶后， -85 ~ -65℃保存，3个月有效期。建议首次使用时将蛋白等分，避免重复冻融循环。
