TNFSF14, also known as tumor necrosis factor ligand superfamily member 14 or LIGHT (homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), is a cytokine belonging to the tumor necrosis factor (TNF) superfamily. It is expressed on the surface of activated T cells, natural killer cells, and immature dendritic cells. TNFSF14 plays a crucial role in regulating immune responses, inflammation, and lymphoid organ development. It can bind to two receptors, herpes virus entry mediator (HVEM) and lymphotoxin beta receptor (LTβR), and modulate various immune functions, including T cell activation, cytokine production, and lymphoid tissue organization.
高活性、高纯度、低内毒素、高批间一致性
SDS-PAGE
2 μg/lane protein was resolved with SDS-PAGE under non-reducing (NR) and reducing (R) conditions and visualized by Coomassie Blue staining.
RP-HPLC
The purity of Mouse LIGHT is greater than 95% as determined by RP-HPLC.
Bioactivity
Measured in a cytotoxicity assayusing HT-29 human colon adenocarcinoma cells, the EC50 for this effect is less than 5ng/ml.
-25 ~ -15℃保存，收到货之后有效期1年。复溶后， 2 ~ 8 °C保存，7 天有效期。复溶后， -85 ~ -65℃保存，3个月有效期。建议首次使用时将蛋白等分，避免重复冻融循环。
