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Opipramol (Ensidon)是一种sigma受体激动剂，它作为一种非典型三环类抗抑郁试剂，被用于广泛性焦虑症（GAD）的研究。

[1] Möller HJ, Volz HP, Reimann IW, Stoll KD. Opipramol for the treatment of generalized anxiety disorder: a placebo-controlled trial including an alprazolam-treated group. J Clin Psychopharmacol. 2001 Feb;21(1):59-65. doi: 10.1097/00004714-200102000-00011. PMID: 11199949.[2]Rao TS, Cler JA, Mick SJ, Dilworth VM, Contreras PC, Iyengar S, Wood PL. Neurochemical characterization of dopaminergic effects of opipramol, a potent sigma receptor ligand, in vivo. Neuropharmacology. 1990 Dec;29(12):1191-7. doi: 10.1016/0028-3908(90)90044-r. PMID: 1963476.