Histamine phosphate是一种作为组胺受体激动剂的有机氮化合物,具有血管扩张作用。它通过影响p38 MAPK/Akt通路发挥抗肿瘤、抗氧化及抗炎活性,并参与免疫调节、肠道生理和神经传递,可用于急性髓系白血病等肿瘤的研究。
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英文别名 (English Synonym) |
Histamine Phosphate |
|
中文名称 (Chinese Name) |
二磷酸组胺 |
|
靶点 (Target) |
Histamine Receptor |
|
通路 (Pathway) |
Neuroscience |
|
CAS号 (CAS NO.) |
51-74-1 |
|
分子式 (Formula) |
C5H9N·2H3O4P |
|
分子量 (Molecular Weight) |
307.14 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于H2O |
-25~-15℃保存，有效期3年
[1] Medina V, Cricco G, Nuñez M, Martín G, Mohamad N, Correa-Fiz F, Sanchez-Jimenez F, Bergoc R, Rivera ES. Histamine-mediated signaling processes in human malignant mammary cells. Cancer Biol Ther. 2006 Nov,5(11):1462-71. doi: 10.4161/cbt.5.11.3273. Epub 2006 Nov 13. PMID: 17012845.[2]Malmberg-Aiello P, Lamberti C, Ghelardini C, Giotti A, Bartolini A. Role of histamine in rodent antinociception. Br J Pharmacol. 1994 Apr,111(4):1269-79. doi: 10.1111/j.1476-5381.1994.tb14883.x. PMID: 8032614, PMCID: PMC1910136.
