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BACE2-IN-1（化合物3l）是一种高选择性BACE2抑制剂，该抑制剂在Ⅱ型糖尿病的相关研究中具有应用潜力。

[1] Ghosh AK, Brindisi M, Yen YC, Lendy EK, Kovela S, Cárdenas EL, Reddy BS, Rao KV, Downs D, Huang X, Tang J, Mesecar AD. Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies. ChemMedChem. 2019 Mar 5;14(5):545-560. doi: 10.1002/cmdc.201800725. Epub 2019 Feb 5. PMID: 30637955; PMCID: PMC6637425.