大鼠β-Amyloid (1-40)是一种在大鼠脑内形成阿尔茨海默病相关老年斑的淀粉样肽。它通过增加45Ca2+内流，诱导海马CA1区神经元变性及细胞凋亡，可用于阿尔茨海默病研究。
[1] MacManus A, Ramsden M, Murray M, Henderson Z, Pearson HA, Campbell VA. Enhancement of (45)Ca(2+) influx and voltage-dependent Ca(2+) channel activity by beta-amyloid-(1-40) in rat cortical synaptosomes and cultured cortical neurons. Modulation by the proinflammatory cytokine interleukin-1beta. J Biol Chem. 2000 Feb 18;275(7):4713-8. doi: 10.1074/jbc.275.7.4713. PMID: 10671502.[2]Prediger RD, Franco JL, Pandolfo P, Medeiros R, Duarte FS, Di Giunta G, Figueiredo CP, Farina M, Calixto JB, Takahashi RN, Dafre AL. Differential susceptibility following beta-amyloid peptide-(1-40) administration in C57BL/6 and Swiss albino mice: Evidence for a dissociation between cognitive deficits and the glutathione system response. Behav Brain Res. 2007 Feb 27;177(2):205-13. doi: 10.1016/j.bbr.2006.11.032. Epub 2006 Dec 27. PMID: 17194489.
