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Zanapezil (TAK-147) free base是一种有效、可逆、选择性的乙酰胆碱酯酶（AChE）抑制剂，能适度抑制毒蕈碱M1/M2受体，可用于阿尔茨海默症早期研究。

[1] Hirai K, Kato K, Nakayama T, Hayako H, Ishihara Y, Goto G, Miyamoto M. Neurochemical effects of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-b enzazepin-8-yl)-1-propanone fumarate (TAK-147), a novel acetylcholinesterase inhibitor, in rats. J Pharmacol Exp Ther. 1997 Mar;280(3):1261-9. PMID: 9067312.[2]Hatip-Al-Khatib I, Takashi A, Egashira N, Iwasaki K, Fujiwara M. Comparison of the effect of TAK-147 (zanapezil) and E-2020 (donepezil) on extracellular acetylcholine level and blood flow in the ventral hippocampus of freely moving rats. Brain Res. 2004 Jun 25;1012(1-2):169-76. doi: 10.1016/j.brainres.2004.03.067. PMID: 15158174.