永利3044(中国集团)有限公司官网

Umibecestat (CNP520)是一种有效的BACE-1抑制剂，对人源和鼠源BACE-1的IC50值分别为11 nM与10 nM，可用于阿尔茨海默病研究。

[1] Neumann U, Ufer M, Jacobson LH, Rouzade-Dominguez ML, Huledal G, Kolly C, Lüönd RM, Machauer R, Veenstra SJ, Hurth K, Rueeger H, Tintelnot-Blomley M, Staufenbiel M, Shimshek DR, Perrot L, Frieauff W, Dubost V, Schiller H, Vogg B, Beltz K, Avrameas A, Kretz S, Pezous N, Rondeau JM, Beckmann N, Hartmann A, Vormfelde S, David OJ, Galli B, Ramos R, Graf A, Lopez Lopez C. The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease. EMBO Mol Med. 2018 Nov;10(11):e9316. doi: 10.15252/emmm.201809316. PMID: 30224383; PMCID: PMC6220303.