Paliperidone(9-Hydroxyrisperidone)是利培酮的主要活性代谢物,作为一种抗精神病药物,通过拮抗多巴胺D2受体和5-HT2A受体发挥疗效,并对α1、α2肾上腺素能受体及H1组胺受体具有拮抗作用,可用于治疗精神分裂症。
|
英文别名 (English Synonym) |
Paliperidone |
|
中文名称 (Chinese Name) |
9-羟基利培酮 |
|
靶点 (Target) |
Dopamine Receptor |
|
通路 (Pathway) |
Neuroscience |
|
CAS号 (CAS NO.) |
144598-75-4 |
|
分子式 (Formula) |
C23H27FN4O3 |
|
分子量 (Molecular Weight) |
426.48 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Gassó P, Mas S, Molina O, Bernardo M, Lafuente A, Parellada E. Neurotoxic/neuroprotective activity of haloperidol, risperidone and paliperidone in neuroblastoma cells. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Jan 10,36(1):71-7. doi: 10.1016/j.pnpbp.2011.08.010. Epub 2011 Aug 22. PMID: 21878360.[2]Boyda HN, Procyshyn RM, Tse L, Yuen JWY, Honer WG, Barr AM. A comparison of the metabolic side-effects of the second-generation antipsychotic drugs risperidone and paliperidone in animal models. PLoS One. 2021 Jan 28,16(1):e0246211. doi: 10.1371/journal.pone.0246211. PMID: 33508013, PMCID: PMC7842964.
