Nilutamide (Nilandron)是一种口服活性的非甾体雄激素受体拮抗剂,能选择性结合雄激素受体,而对孕激素、雌激素或糖皮质激素受体无亲和力,可用于前列腺癌研究并具有抗血吸虫作用。
|
英文别名 (English Synonym) |
Nilutamide |
|
中文名称 (Chinese Name) |
尼鲁米特 |
|
靶点 (Target) |
Androgen Receptor |
|
通路 (Pathway) |
Endocrinology and Hormones |
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CAS号 (CAS NO.) |
63612-50-0 |
|
分子式 (Formula) |
C12H10F3N3O4 |
|
分子量 (Molecular Weight) |
317.22 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Babany G, Tinel M, Letteron P, Freneaux E, Berson A, Larrey D, Pessayre D. Inhibitory effects of nilutamide, a new androgen receptor antagonist, on mouse and human liver cytochrome P-450. Biochem Pharmacol. 1989 Mar 15,38(6):941-7. doi: 10.1016/0006-2952(89)90284-0. PMID: 2930595.[2]Keiser J, Vargas M, Vennerstrom JL. Activity of antiandrogens against juvenile and adult Schistosoma mansoni in mice. J Antimicrob Chemother. 2010 Sep,65(9):1991-5. doi: 10.1093/jac/dkq233. Epub 2010 Jun 24. PMID: 20576641, PMCID: PMC2920177.
