Monobenzone作为强效皮肤脱色剂，通过靶向核糖核苷酸还原酶小亚基RRM2蛋白抑制其活性，在急性髓系白血病模型中表现出显著抗增殖效应。该化合物可阻断DNA生物合成进程，诱导细胞周期停滞与程序性死亡，同时因其色素脱失特性被应用于白癜风发病机制研究。
|
英文别名 (English Synonym) |
Monobenzone |
|
中文名称 (Chinese Name) |
4-苄氧基苯酚 |
|
靶点 (Target) |
Others |
|
通路 (Pathway) |
Others |
|
CAS号 (CAS NO.) |
103-16-2 |
|
分子式 (Formula) |
C13H12O2 |
|
分子量 (Molecular Weight) |
200.23 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Dong J, Zhong T, Xu Z, Chen H, Wang X, Yang L, Lou Z, Xu Y, Hou T, Xu R, Zhu W, Shao J. Identification of Monobenzone as a Novel Potential Anti-Acute Myeloid Leukaemia Agent That Inhibits RNR and Suppresses Tumour Growth in Mouse Xenograft Model. Cancers (Basel). 2022 Sep 27;14(19):4710. doi: 10.3390/cancers14194710. PMID: 36230632; PMCID: PMC9564123. [2] Zhu Y, Wang S, Xu A. A mouse model of vitiligo induced by monobenzone. Exp Dermatol. 2013 Jul;22(7):499-501. doi: 10.1111/exd.12184. PMID: 23800067.
