Ulipristal acetate (CDB-2914) 是一种口服有效的选择性孕酮受体调节剂（SPRM），能够特异性诱导平滑肌瘤细胞发生自噬反应。该化合物在子宫肌瘤等良性妇科疾病的治疗研究中显示出应用潜力。
|
英文别名 (English Synonym) |
Ulipristal Acetate |
|
中文名称 (Chinese Name) |
醋酸乌利司他 |
|
靶点 (Target) |
Estrogen/progestogen Receptor |
|
通路 (Pathway) |
Endocrinology and Hormones |
|
CAS号 (CAS NO.) |
126784-99-4 |
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分子式 (Formula) |
C30H37NO4 |
|
分子量 (Molecular Weight) |
475.62 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Del Bello B, Marcolongo P, Ciarmela P, Sorbi F, Petraglia F, Luisi S, Maellaro E. Autophagy up-regulation by ulipristal acetate as a novel target mechanism in the treatment of uterine leiomyoma: an in vitro study. Fertil Steril. 2019 Dec;112(6):1150-1159. doi: 10.1016/j.fertnstert.2019.08.007. PMID: 31843092. [2] Pohl O, Harvey PW, McKeag S, Boley SE, Gotteland JP. Carcinogenicity and chronic rodent toxicity of the selective progesterone receptor modulator ulipristal acetate. Curr Drug Saf. 2013 Apr;8(2):77-97. doi: 10.2174/15748863112079990012. PMID: 23656453.
