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Rucaparib phosphate，又称瑞卡帕布磷酸盐或鲁卡帕尼磷酸盐，是AG14447的磷酸盐形式，是可口服的PARP抑制剂，是第一个和temozolomide联用于临床实验的PARP抑制剂。Rucaparib phosphate也是六磷酸己糖脱氢酶(H6PD)的抑制剂，逆转异种移植模型中前列腺癌耐药性。

参考文献

[1] Thomas HD, Calabrese CR, Batey MA, et al. Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol Cancer Ther. 2007 Mar;6(3):945-56. doi: 10.1158/1535-7163.MCT-06-0552(IF:4.856).

[2] Daniel RA, Rozanska AL, Mulligan EA, et, al. Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699. Br J Cancer. 2010 Nov 9;103(10):1588-96. doi: 10.1038/sj.bjc.6605946(IF:5.416).

[3] Daniel RA, Rozanska AL, Thomas HD, et, al. Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma. Clin Cancer Res. 2009 Feb 15;15(4):1241-9. doi: 10.1158/1078-0432.CCR-08-1095(IF:8.911).

[4] Li J, Berk M, Alyamani M, et, al. Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation. Sci Transl Med. 2021 May 26;13(595):eabe8226. doi: 10.1126/scitranslmed.abe8226(IF:17.161).

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