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Ibuprofen ((±)-Ibuprofen, Dolgesic, NSC 256857, NSC256857, Advil, Motrin, Brufen)，又称布洛芬、异丁苯丙酸或异丁洛芬，是一种COX-1/2抑制剂，IC₅₀分别为13 μM和370 μM，具有抗炎、镇痛、抗癌和解热的作用，临床上用于治疗风湿性关节炎、类风湿性关节炎、感冒发热等。

参考文献

1.Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7.

2.Hassan Akrami, et al. Inhibitory effect of ibuprofen on tumor survival and angiogenesis in gastric cancer cell. Tumour Biol. 2015 May;36(5):3237-43.

3.Sharon M Rymut, et al. Ibuprofen regulation of microtubule dynamics in cystic fibrosis epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L317-27.

4.Emmanuelle Bignon, et al. Ibuprofen and ketoprofen potentiate UVA-induced cell death by a photosensitization process. Sci Rep. 2017 Aug 21;7(1):8885.

5.Nathan D Pennock, et al. Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer. J Immunother Cancer. 2018 Oct 1;6(1):98.

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