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RG108 (RG-108, N-Phthalyl-L-tryptophan)，又称N-酞酰-L-色氨酸，是非核苷类似物，是表观遗传调控剂和去甲基化剂，DNA甲基转移酶(DNMTs)的抑制剂，IC₅₀为115 nM，靶向DNA甲基转移酶的催化结构域，促进肿瘤细胞中抑癌基因的去甲基化，但对着丝粒卫星序列的甲基化无作用。

参考文献

1.Brueckner B, et al. Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res. 2005 Jul 15;65(14):6305-11.

2.Schirrmacher E, et al. Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases. Bioconjug Chem. 2006 Mar-Apr;17(2):261-6.

3.Pasha Z, et al. Efficient non-viral reprogramming of myoblasts to stemness with a single small molecule to generate cardiac progenitor cells. PLoS One. 2011;6(8):e23667.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。