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Sp-cAMPS，属于cAMP类似物，是PKA激活剂，可在体内和体外诱导GEFI（也称为Epac（由cAMP直接激活的交换蛋白））和GEFII对Rap1的鸟嘌呤核苷酸交换因子活性。胰高血糖素刺激的Ca²⁺水平升高可被Sp-cAMPS模拟，并可被Rp-camp预处理抑制。这些结果表明胰高血糖素可以通过cAMP和cAMP依赖蛋白激酶提高细胞内Ca²⁺水平。  

参考文献

[1] P A Connelly, et al. A study of the mechanism of glucagon-induced protein phosphorylation in isolated rat hepatocytes using (Sp)-cAMPS and (Rp)-cAMPS, the stimulatory and inhibitory diastereomers of adenosine cyclic 3',5'-phosphorothioate. J Biol Chem. 1987 Mar 25;262(9):4324-32.

[2] G Dominguez, et al. Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure. Brain Struct Funct. 2016 Mar;221(2):865-77.

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