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Cytochalasin D (Zygosporin A, NSC 209835, NSC209835)，又称细胞松弛素D，是一种有效、细胞渗透性的肌动蛋白聚合选择性抑制剂，IC50值为25 nM，由真菌产生，通过与G-actin或F-actin结合来抑制它们与cofilin的相互作用，降低了肌动蛋白聚合和解聚的速率。此外，Cytochalasin D可以激活p53途径，并诱导细胞周期阻滞。

参考文献

1.Huang FY, et al. Cytochalasin D, a tropical fungal metabolite, inhibits CT26 tumor growth and angiogenesis. Asian Pac J Trop Med. 2012 Mar;5(3):169-74.

2.Salu KJ, et al. Effects of cytochalasin D-eluting stents on intimal hyperplasia in a porcine coronary artery model. Cardiovasc Res. 2006 Feb 1;69(2):536-44.

3.Shoji K, et al. Cytochalasin D acts as an inhibitor of the actin-cofilin interaction. Biochem Biophys Res Commun. 2012 Jul 20;424(1):52-7.

4.Flanagan MD, et al. Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin. J Biol Chem. 1980 Feb 10;255(3):835-8.

5.Mariadelva Catalano, et al. Inhibiting extracellular vesicles formation and release: a review of EV inhibitors. J Extracell Vesicles. 2020; 9(1): 1703244.

6.Ken-Ichi Wada, et al. Hippo pathway regulation by cell morphology and stress fibers. 2011 Sep;138(18):3907-14.

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃干燥保存，避免反复冻融。

Q：DMSO的溶解度是多少？

A：20mg/ml。