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The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.

推荐稀释比 WB: 1/1000-1/5000; FC: 1/200-1/2000

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Flow cytometric analysis of Endoplasmic reticulum aminopeptidase 1 expression in HT-1080 cells using Endoplasmic reticulum aminopeptidase 1 antibody . Green, isotype control; red, Endoplasmic reticulum aminopeptidase 1.

Western blotting analysis using endoplasmic reticulum aminopeptidase 1 antibody . Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with endoplasmic reticulum aminopeptidase 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively. Image was developed using NaQ™ ECL Substrate Kit .

Western blotting analysis using endoplasmic reticulum aminopeptidase 1 antibody . Endoplasmic reticulum aminopeptidase 1 expression in wild-type (WT) and endoplasmic reticulum aminopeptidase 1 (ERAP1) shRNA knockdown (KD) HT-1080 cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with endoplasmic reticulum aminopeptidase 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively. Image was developed using NaQ™ ECL Substrate Kit .

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