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Dusquetide (SGX942)是一种第一类天然防御调节因子(IDR)。它通过结合p62来调节PAMPs和DAMPs的天然免疫应答。该化合物在减轻炎症和增强细菌感染清除方面均显示出活性。

[1] Kudrimoti M, Curtis A, Azawi S, Worden F, Katz S, Adkins D, Bonomi M, Elder J, Sonis ST, Straube R, Donini O. Dusquetide: A novel innate defense regulator demonstrating a significant and consistent reduction in the duration of oral mucositis in preclinical data and a randomized, placebo-controlled phase 2a clinical study. J Biotechnol. 2016 Dec 10,239:115-125. doi: 10.1016/j.jbiotec.2016.10.010. Epub 2016 Oct 13. PMID: 27746305.