4-Br-Bnlm是一种选择性葡萄糖调节蛋白94（Grp94）抑制剂（EC50=0.96µM），它通过降低突变型和野生型心肌蛋白的错误折叠水平，促进毒性蛋白的清除，从而减轻心肌细胞毒性。
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2~8℃避光保存，有效期3年。
[1] Stothert AR, Suntharalingam A, Huard DJ, Fontaine SN, Crowley VM, Mishra S, Blagg BS, Lieberman RL, Dickey CA. Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma. Hum Mol Genet. 2014 Dec 15;23(24):6470-80. doi: 10.1093/hmg/ddu367. Epub 2014 Jul 15. PMID: 25027323; PMCID: PMC4240202.
[2]Stothert AR, Suntharalingam A, Tang X, Crowley VM, Mishra SJ, Webster JM, Nordhues BA, Huard DJE, Passaglia CL, Lieberman RL, Blagg BSJ, Blair LJ, Koren J 3rd, Dickey CA. Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma. Sci Rep. 2017 Dec 20;7(1):17951. doi: 10.1038/s41598-017-18344-4. PMID: 29263415; PMCID: PMC5738387.
