永利3044(中国集团)有限公司官网

Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) 是一种高效的ATP竞争性泛I类PI3K抑制剂，对PI3Kα、δ、β和γ亚型具有纳摩尔级的抑制活性。该化合物表现出极高的激酶选择性，除mTOR外，对其他激酶的抑制活性均显著降低，并展现出优异的体内抗肿瘤效果。

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2~8℃避光保存，有效期3年。

[1] Liu N, Rowley BR, Bull CO, Schneider C, Haegebarth A, Schatz CA, Fracasso PR, Wilkie DP, Hentemann M, Wilhelm SM, Scott WJ, Mumberg D, Ziegelbauer K. BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models. Mol Cancer Ther. 2013 Nov;12(11):2319-30. doi: 10.1158/1535-7163.MCT-12-0993-T. Epub 2013 Oct 29. PMID: 24170767.