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FoxO3a is a transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.

推荐稀释比 WB:1/1000-1/2000; IF:1/50-1/200

Western blot analysis of FOXO3A in MCF-7 lysates using FOXO3 antibody.

Immunofluorescence analysis of FOXO3 in Hela using FoxO3a antibody.

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