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The interleukin (IL)-12 family of cytokines, including IL12 and IL 23, play an important role in driving aberrant Th1 and Th17 immune responses in patients with Crohn's disease (CD) . Targeting this pathway has opened new avenues for therapeutic intervention.

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ELISA Data 1:Immobilized Cynomolgus IL-23 alpha&IL-12 beta, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human IL-23R, hFc Tag with the EC50 of 0.17μg/ml determined by ELISA .

SPR Data: Human IL-23R, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus IL-23 alpha&IL-12 beta, His Tag with an affinity constant of 4.05 nM as determined in SPR assay .

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