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CD37 is a 40-52 kD type II transmembrane protein, also known as tetraspanin-26.  It is a member of the transmembrane tetraspanin family. It can interact with integrins and other transmembrane 4 superfamily members (CD53, CD81, CD82).  CD37 is expressed predominantly on B cells; low expression is detected on T cells and myeloid cells.  No expression is reported on NK cells and plasma cells.  It is involved in regulation of T cell proliferation.

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Flow cytometry analysis of Human peripheral blood lymphocytes stained with CD37 antibody (7E9C3FITC)

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