This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling.
推荐稀释比 IHC:1/100-1/200;FC:1/50-1/100;ELISA:1/10000
Immunohistochemistry analysis of paraffin-embedded human rectum cancer tissues using TCF7 antibody.
-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。
