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Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and cell differentiation. Additionally, Bcl-6 negatively regulates NFκB expression, thereby inhibiting NFκB-mediated cellular functions.HDAC- and silent information regulator (SIR)-2-dependent acet-ylation of Bcl-6 causes downregulation of activity by inhibiting the ability of Bcl-6 to recruit complexes containing histone deacetylases (HDACs).

推荐稀释比 IHC:1/100-1/200

Immunohistochemistry analysis of paraffin-embedded Tonsil using Bcl6 antibody.High-pressure and temperature Tris-EDTA pH 8.0 was used for antigen retrieval.

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