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E3 ubiquitin-protein ligase synoviolin is an enzyme that in humans is encoded by the SYVN1 gene. This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. This gene and the mitochondrial ribosomal protein L49 gene use in their respective 3' UTRs some of the same genomic sequence. Sequence analysis identified two transcript variants that encode different isoforms.

推荐稀释比 WB:1/500-1/1000;IHC-P:1/50-1/100;ICC/IF:1/50

Western blot analysis of SYVN1 in lysates of A549,HeLa,HEK-293 and HepG2 using SYVN1 antibody.

Immunohistochemistry analysis of paraffin-embedded Human liver cancer using SYVN1 antibody.High pressure and temperature Tris/EDTA (PH 9.0) used for antigen retrieval.The brown color represents the positive signal observed with SYVN1 antibody.

Immunocytochemistry analysis of SYVN1(green) in HeLa cells using SYVN1 antibody,and DAPI(blue).

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