Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity).

推荐稀释比 WB:1/500-1/1000;IF:1:50/1:200

Western blot analysis of Dnmt3b in HeLa ,3T3，C6 lysates using Dnmt3b antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。