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Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.

推荐稀释比 WB:1/500-1/1000;IF:1/50-1/200;FC:1/50-1/100

Western blot analysis of LXR alpha in Jurkat lysates using LXR alpha antibody.

Western blot analysis of LXR alpha in Jurkat，3T3，PC-12 lysates using LXR alpha antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。