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EGFR (Epidermal Growth Factor Receptor) protein is a receptor tyrosine kinase (RTK), belonging to the tyrosine kinase receptor family. EGFR is widely expressed in various cell types, including epithelial cells, nerve cells, and muscle cells. Activation of EGFR typically occurs through binding to its ligand (such as EGF), triggering its autophosphorylation and activating its tyrosine kinase activity. Activated EGFR then initiates a series of signaling pathways, including Ras-MAPK, PI3K-Akt, among others, thereby influencing cell physiological functions.EGFR plays a significant role in many types of cancers because abnormal EGFR signaling pathways can lead to excessive cell proliferation and malignant transformation. Therefore, EGFR has become one of the important targets for cancer treatment, with anti-cancer drugs targeting EGFR, such as EGFR inhibitors, being widely researched and applied in clinical therapy. EGFR holds importance in cell biology and cancer research, playing a crucial role in understanding cell signaling and cancer development mechanisms.

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SDS-PAGE

Figure 1.On SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA

Figure 2.Biotinylated Cynomolgus EGFR Protein; His-Avi Tag was immobilized at 1 μg/ml (100 μL/well) on streptavidin precoated. Increasing concentrations of Anti-Human EGFR hIgG1 Antibody were added.

-85 ~ -65℃保存，收到货之日起，6个月有效期。避免反复冻融，建议等分分装为一次实验使用量，分装后，-80℃冻存。