This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
Western
Western blot analysis of Insulin Receptor in HepG2 (1), HEK293 (2), Jurkat (3), Hela (4), THP-1 (5), NIH/3T3 (6), COS7 (7), and PC-3 (8) cell lysate using Insulin Receptor antibody.
Immunocytochemistry
Immunocytochemistry analysis of Insulin Receptor in Hela cells using Insulin Receptor antibody (green),and DAPI(blue). Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Flow
Flow Cytometry analysis of HL-60 cells using Insulin Receptor antibody (green) and negative control (red).
-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。
