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[ 1 ]Psychedelics elicit their effects by 5-HT2A receptor-mediated Gi signalling

[ 2 ]Immune checkpoint HLA-E:CD94-NKG2A mediates evasion of circulating tumor cells from NK cell surveillance

[ 3 ]Divergent tumor immunity determined by bacteria-cancer cell engagement

[ 4 ]Mechanism of activation and biased signaling in complement receptor C5aR1

[ 5 ]Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling

[ 6 ]Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition

[ 7 ]Engineered probiotics recruit CAR macrophages and establish immune memory to eradicate heterogeneous glioblastoma in mice

[ 8 ]An SLCO2B1 mRNA Isoform Acts as a Noncoding RNA to Drive Cancer Progression by Triggering Protein Biosynthesis

[ 9 ]A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer

[ 10 ]A viral protein orchestrates rice ethylene signaling to coordinate viral infection and insect vector-mediated transmission

[ 11 ]mRNA Vaccines Against SARS-CoV-2 Variants Delivered by Lipid Nanoparticles Based on Novel Ionizable Lipids

[ 12 ]Targeting FAPα-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models

[ 13 ]Dynamically Deformable Protein Delivery Strategy Disassembles Neutrophil Extracellular Traps to Prevent Liver Metastasis

[ 14 ]Simultaneous Deep Tracking of Stem Cells by Surface Enhanced Raman Imaging Combined with Single-Cell Tracking by NIR-II Imaging in Myocardial Infarction

[ 15 ]Phytophthora targets plant extracellular vesicles to promote infection

[ 16 ]Structural basis for positive allosteric regulation of CB2 receptor

[ 17 ]Peptide-functionalized membrane camouflage for endogenous H2S-induced photothermal immunotherapy of orthotopic colorectal cancer

[ 18 ]Spatial- and Valence-Matched Neutralizing DNA Nanostructure Blocks Wild-Type SARS-CoV-2 and Omicron Variant Infection

[ 19 ]Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy

[ 20 ]Programmable CRISPR-Cas9 microneedle patch for long-term capture and real-time monitoring of universal cell-free DNA

[ 21 ]CRISPR/Cas9 Screens Reveal that Hexokinase 2 Enhances Cancer Stemness and Tumorigenicity by Activating the ACSL4-Fatty Acid β-Oxidation Pathway

[ 22 ]Antihypertension Nanoblockers Increase Intratumoral Perfusion of Sequential Cytotoxic Nanoparticles to Enhance Chemotherapy Efficacy against Pancreatic Cancer

[ 23 ]Tumor–Antigen Activated Dendritic Cell Membrane-Coated Biomimetic Nanoparticles with Orchestrating Immune Responses Promote Therapeutic Efficacy against Glioma

[ 24 ]Synthesis of scarless circular RNAs expressing long-acting GLP-1RAs for type 2 diabetes therapy

[ 25 ]Enhancement of T cell infiltration via tumor-targeted Th9 cell delivery improves the efficacy of antitumor immunotherapy of solid tumors

[ 26 ]Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine

[ 27 ]LDHB Deficiency in Fibroblasts Induces Lactate-Mediated Inflammatory Reprogramming that Promotes Breast Cancer Metastasis

[ 28 ]Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy

[ 29 ]μ-opioid receptor agonist facilitates circulating tumor cell formation in bladder cancer via the MOR/AKT/Slug pathway: a comprehensive study including randomized controlled trial

[ 30 ]Resolving the lineage relationship between malignant cells and vascular cells in glioblastomas

[ 31 ]RGD peptide modified platinum nanozyme Co-loaded glutathione-responsive prodrug nanoparticles for enhanced chemo-photodynamic bladder cancer therapy

[ 32 ]Brain-Targeted HFn-Cu-REGO Nanoplatform for Site-Specific Delivery and Manipulation of Autophagy and Cuproptosis in Glioblastoma

[ 33 ]FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ

[ 34 ]Manganese-coordinated mRNA vaccines with enhanced mRNA expression and immunogenicity induce robust immune responses against SARS-CoV-2 variants

[ 35 ]Gli1 promotes epithelial–mesenchymal transition and metastasis of non-small cell lung carcinoma by regulating snail transcriptional activity and stability

[ 36 ]A Heterojunction Structured WO2.9-WSe2 Nanoradiosensitizer Increases Local Tumor Ablation and Checkpoint Blockade Immunotherapy upon Low Radiation Dose

[ 37 ]PARP inhibitors restore NK cell function via secretory crosstalk with tumor cells in prostate cancer

[ 38 ]Intercellular Horizontal Transfer of TXNDC5 mRNA via Extracellular Vesicles Contributes to Tumor-Associated Macrophage-Mediated Prostate Cancer Metastasis

[ 39 ]Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress-Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

[ 40 ]Dual PD-1/IL-2Rα targeting restores CD8+ T cell fitness via STAT5/CD47 axis in SMARCA4-deficient NSCLC

[ 41 ]Non-genetically reprogrammed meta-neutrophils potentiate chemo-immunotherapy against lung metastatic triple-negative breast cancer

[ 42 ]Nanocollision promotes locomotion of dendritic cells for tumor therapy

[ 43 ]iRGD Modified Chemo-immunotherapeutic Nanoparticles for Enhanced Immunotherapy against Glioblastoma

[ 44 ]Biomimetic neutrophil and macrophage dual membrane-coated nanoplatform with orchestrated tumor-microenvironment responsive capability promotes therapeutic efficacy against glioma

[ 45 ]Rare Natural SNP Activates SHOOT APICAL MERISTEM ENLARGER1 to Increase Branch Number and Silique Number on the Main Inflorescence in Brassica napus

[ 46 ]LsMAPK6 Phosphorylates the LsCO Protein to Enhance Its Stability and Transcriptional Activity, Promoting Floral Transition Upon High Temperatures in Lettuce

[ 47 ]AMBRA1 Promotes TGFβ Signaling via Nonproteolytic Polyubiquitylation of Smad4

[ 48 ]Irradiation induces DJ-1 secretion from esophageal squamous cell carcinoma cells to accelerate metastasis of bystander cells via a TGF-β1 positive feedback loop

[ 49 ]The PuHK2-PuHP5-PuRR9 cascade recruits PuZFP1 to regulate cytokinin and salt tolerance in poplar

[ 50 ]ABA orchestrates the expression of SWEET16 for sugar accumulation via phosphorylation and transcriptional mechanisms in citrus

[ 51 ]Reprogramming the fibrotic niche with an inhalable “weeding and root removal” RNA platform for idiopathic pulmonary fibrosis therapy

[ 52 ]PtoHY5 integrates photoperiodic signals with the ABA pathway to coordinate growth cessation and dormancy in Populus

[ 53 ]Biocompatible therapeutic albumin/genipin bioglue for postoperative wound adhesion and residual tumor ablation

[ 54 ]Biomimetic trident lipid anchoring enables stable neutrophil-based combination therapy

[ 55 ]Loss of internal structural order induced by freezing and Lyophilization correlates with reduced in vitro activity of mRNA lipid nanoparticles

[ 56 ]USP13 promotes enzalutamide resistance by catalyzing depolyubiquitination of PCMT1 in prostate cancer

[ 57 ]CRMP2 inhibits metastasis formation by impairing ILF3-dependent stabilization of CXCL10 mRNA in breast cancer

[ 58 ]PSMD11 stabilizes PGM3 by antagonizing Parkin to promote bladder cancer progression through energy metabolism reprogramming

[ 59 ]A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy

[ 60 ]A Ralstonia solanacearum effector targets TGA transcription factors to subvert salicylic acid signaling

[ 61 ]AUXIN RESPONSE FACTOR7 integrates gibberellin and auxin signaling via interactions between DELLA and AUX/IAA proteins to regulate cambial activity in poplar

[ 62 ]FTO promotes multiple myeloma progression by posttranscriptional activation of HSF1 in an m6A-YTHDF2-dependent manner

[ 63 ]Programmable engineered bacteria manipulate metabolism and remodel the TME in situ for enhancing adoptive cell therapy

[ 64 ]Exosomal circTUBGCP4 promotes vascular endothelial cell tipping and colorectal cancer metastasis by activating Akt signaling pathway

[ 65 ]LncRNA SPOCD1-AS from ovarian cancer extracellular vesicles remodels mesothelial cells to promote peritoneal metastasis via interacting with G3BP1

[ 66 ]Brain-Targeting Nanoplatform Repurposing Silymarin for Enhanced GBM Immunotherapy via Synergistic Mitochondrial Suppression

[ 67 ]A nanodrug combining CD47 and sonodynamic therapy efficiently inhibits osteosarcoma deterioration

[ 68 ]Decrease of circARID1A retards glioblastoma invasion by modulating miR-370-3p/ TGFBR2 pathway

[ 69 ]CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling

[ 70 ]TFCP2L1 suppresses breast cancer progression by promoting ferroptosis through direct and PI3K/AKT-mediated inhibition of GPX4

[ 71 ]In situ gas foaming based on magnesium particle degradation: A novel approach to fabricate injectable macroporous hydrogels

[ 72 ]The combination of gemcitabine and ginsenoside Rh2 enhances the immune function of dendritic cells against pancreatic cancer via the CARD9-BCL10-MALT1 / NF-κB pathway

[ 73 ]Integrated genome-wide domestication and association analyses reveal the complex genetic basis of parthenocarpy during cucumber domestication

[ 74 ]Valproic acid reverses macrophage-mediated temozolomide resistance in macrophage-rich gliomas

[ 75 ]RNA m6A methylation promotes the formation of vasculogenic mimicry in hepatocellular carcinoma via Hippo pathway

[ 76 ]N4BP3 promotes breast cancer metastasis via NEDD4-mediated E-cadherin ubiquitination and degradation

[ 77 ]Mitochondrial LINC00942 activates complex I and inhibits ferroptosis through interacting with GRSF1 in liver cancer

[ 78 ]Carrier-free multifunctional nanomedicine for intraperitoneal disseminated ovarian cancer therapy

[ 79 ]Unleashing T cell surveillance for the eradication of quiescent persister tumor cells resistant to neoadjuvant chemotherapy

[ 80 ]Metabolic modulation of CtBP dimeric status impacts the repression of DNA damage repair genes and the platinum sensitivity of ovarian cancer

[ 81 ]MS4A4A promotes macrophages M2 polarization via NF-κB /JAK-STAT6 axis, resulting GBM malignant progression

[ 82 ]Control of grain size in rice by TGW3 phosphorylation of OsIAA10 through potentiation of OsIAA10-OsARF4-mediated auxin signaling.

[ 83 ]Cancer-associated fibroblast-induced lncRNA UPK1A-AS1 confers platinum resistance in pancreatic cancer via efficient double-strand break repair

[ 84 ]VvMYB44–VvERF045 complex is involved in abscisic acid-induced sugar accumulation by activating VvSPS4 expression in grapes

[ 85 ]Synergistic cell-cycle repression by HDAC/EZH2 co-targeting in H3K27-altered diffuse midline glioma

[ 86 ]Prrx1 promotes stemness and angiogenesis via activating TGF-β/smad pathway and upregulating proangiogenic factors in glioma

[ 87 ]Carrier-free delivery of thymopentin-regulated injectable nanogels via an enhanced cancer immunity cycle against melanoma metastasis

[ 88 ]A dual-function movement protein regulates viral replication suppression and movement facilitation in plant viral infections

[ 89 ]Overexpression of TRYPTOPHAN DECARBOXYLASE from Aegilops variabilis enhances flavonoid biosynthesis and germination in wheat

[ 90 ]L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis

[ 91 ]PRMT5 methylating SMAD4 activates TGF-β signaling and promotes colorectal cancer metastasis

[ 92 ]NAD+ supplementation limits triple-negative breast cancer metastasis via SIRT1-P66Shc signaling

[ 93 ]S100A14 suppresses metastasis of nasopharyngeal carcinoma by inhibition of NF-kB signaling through degradation of IRAK1

[ 94 ]DB-PTZ: A Novel NIR-II AIE Photosensitizer for Image-Guided Photothermal and Photodynamic Therapy of Hepatocellular Carcinoma

[ 95 ]A nanoparticle-containing polycaprolactone implant for combating post-resection breast cancer recurrence

[ 96 ]Preclinical Study of Plasmodium Immunotherapy Combined with Radiotherapy for Solid Tumors

[ 97 ]Circular RNA hsa-circ-0001030 suppresses proliferation and cisplatin tolerance in TSCC via interaction with PKM2

[ 98 ]Transcription factors GmERF1 and GmWRKY6 synergistically regulate low phosphorus tolerance in soybean

[ 99 ]HEAT SHOCK PROTEIN 90.6 interacts with carbon and nitrogen metabolism components during seed development

[ 100 ]Engineering Synthetic CopT/A-Based Genetic Biosensors for miRNA Imaging and Functional Gene Regulation