Mitochondrial targeted drug delivery combined with manganese catalyzed Fenton reaction for the treatment of breast cancer
Xincheng Zhong, Xiaoyan Bao, Haiqing Zhong, Yi Zhou, Zhentao Zhang, Yiying Lu, Qi Dai, Qiyao Yang, Peng Ke, Yiyi Xia, Linjie Wu, Zaiyun Sui, Yan Lu, Min Han, WenHong Xu, Jianqing Gao
Journal：INTERNATIONAL JOURNAL OF PHARMACEUTICS
IF：6.51
DOI：10.1016/j.ijpharm.2022.121810
PMID：35580685
Published：2022-05-14
research field：肿瘤学癌症生物学免疫治疗神经免疫学纳米医学
Abstract
In previous studies, we found that triphenylphosphine-modified doxorubicin (TPP-DOX) can effectively kill drug-resistant tumor cells, but its effect on sensitive tumor cells is weakened. In this research, with albumin from Bovine Serum (BSA) as a carrier, [email protected] ( [email protected] ) nanoparticles were prepared by co-loading TPP-DOX and manganese which can realize the combination of chemotherapy and chemodynamic therapy (CDT). The uniform and stable nano-spherical nanoparticle can promote drug uptake, achieve mitochondrial-targeted drug delivery, increase intracellular reactive oxygen species (ROS) and catalyze the production of highly toxic oxidative hydroxyl radicals (OH·), further inhibiting the growth of both sensitive and drug-resistant MCF-7 cells. Besides, [email protected] can down-regulate the stemness-related proteins and the metastasis-related proteins, potentially decreasing the tumor stemness and metastasis. In vivo experiment indicated that [email protected] was able to exert desired antitumor effect, good tumor targeting and biocompatibility .
本文使用的Yeasen产品
