Multifunctional nanoplatform for photoacoustic imaging-guided combined therapy enhanced by CO induced ferroptosis
Xianxian Yao, Peng Yang, Zhaokui Jin, Qin Jiang, Ranran Guo, Ruihong Xie, Qianjun He, Wuli Yang
Journal：BIOMATERIALS
IF：10.27
DOI：10.1016/j.biomaterials.2019.01.026
PMID：30677556
Published：2019-01-18
research field：肿瘤学药理学肿瘤免疫治疗免疫学炎症研究纳米医学
Abstract
A multifunctional CO/thermo/chemotherapy nanoplatform is here reported, which is composed of mesoporous carbon nanoparticles (MCN) as near infrared (NIR)-responsive drug carrier, doxorubicin (DOX) as chemotherapeutic drug and triiron dodecacarbonyl (FeCO) as thermosensitive CO prodrug. The nanoplatform could absorb near-infrared (NIR) light and convert it into ample heat to trigger CO release and could also release DOX in the acidic tumor microenvironment . More importantly, the generated CO molecules successfully increase cancer cell sensitivity to chemotherapeutics by the ferroptosis pathway. Subsequently, under the guidance of photoacoustic imaging, the [email protected] nanoplatform demonstrates high treatment efficacies in vitro and in vivo by combination of chemotherapy, photothermal therapy and gas therapy. This multifunctional platform with excellent antitumor efficacy has great potential in precision cancer therapy.
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