Synbiotic microcapsules delivering Lactiplantibacillus Plantarum AR113 protect against acute pancreatitis via acetate-mediated modulation of the gut-pancreas axis
Wei Xiao, Yang Fu, Wenfei Qin, Zerun Li, Lianzhong Ai, Guangqiang Wang, Yue Zeng
Journal：Journal of Functional Foods
IF：3.9
DOI：10.1016/j.jff.2026.107327
PMID：
Published：2026-05-04
research field：生物医学工程免疫学胃肠病学微生物学代谢学
Abstract
Acute pancreatitis (AP) urgently requires new therapeutic strategies. Here, we developed a maltose-alginate synbiotic microcapsule (AM-AR113) for intestinal delivery of Lactiplantibacillus plantarum AR113 and evaluated its protective effect in AP. AM-AR113 improved bacterial survival during storage and simulated gastrointestinal transit. In AP mice, AM-AR113 reduced pancreatic and ileal injury and decreased serum IL-6, TNF-α, and IL-1β. It also improved gut microbiota dysbiosis and markedly increased fecal acetate. Using an acetate kinase-deficient mutant (AR113Δ0187), we found that reduced acetate production was accompanied by weakened protection, whereas exogenous acetate reproduced the major protective effects. Acetate restored intestinal barrier-related markers, reduced serum DAO, LPS, and FITC-dextran levels, and was associated with reduced pancreatic MCP-1, decreased M1-associated inflammatory markers, increased Cd206 expression, and reduced Hdac3 expression. These findings suggest that AM-AR113 protects against AP at least partly through acetate-associated gut-pancreas axis regulation.
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